Free UK mainland delivery over £50
14-Day Returns Policy
Carbon Neutral Deliveries
Rated 4.96 ★★★★★
Skin quiz Not sure where to start? Answer a few quick questions and we'll suggest a routine for your skin. Take the quiz The Derma Club Earn points every time you shop Swap your points for money off, plus 250 bonus points when you join. Join the club
Connect with us
Suggestions
Featured Products
Environ Skin Essential Sequence Edit
Environ
Environ Skin Essential Sequence Edit
Moisturiser
Cleanser
Toner
Environ Skin Essential Sequence Edit
Environ
Environ Skin Essential Sequence Edit
From £214.00
Gifts Worth £117
Size
Dermalogica Dynamic Skin Recovery SPF50
Dermalogica
Dermalogica Dynamic Skin Recovery SPF50
Size
Dermalogica Dynamic Skin Recovery SPF50 Dermalogica Dynamic Skin Recovery SPF50, view 2
Dermalogica
Dermalogica Dynamic Skin Recovery SPF50
From £28.00
Subscribe & save 10%
Suggestions
Featured Products
Environ Skin Essential Sequence Edit
Environ
Environ Skin Essential Sequence Edit
Moisturiser
Cleanser
Toner
Environ Skin Essential Sequence Edit
Environ
Environ Skin Essential Sequence Edit
From £214.00
Gifts Worth £117
Size
Dermalogica Dynamic Skin Recovery SPF50
Dermalogica
Dermalogica Dynamic Skin Recovery SPF50
Size
Dermalogica Dynamic Skin Recovery SPF50 Dermalogica Dynamic Skin Recovery SPF50, view 2
Dermalogica
Dermalogica Dynamic Skin Recovery SPF50
From £28.00
Subscribe & save 10%
Added to bag
Circadia Serum 71, view 2
Circadia Serum 71, view 3
Circadia Serum 71, view 4
Circadia Serum 71, view 5
Circadia Serum 71, view 6
Circadia Serum 71, view 2
Circadia Serum 71, view 3
Circadia Serum 71, view 4
Circadia Serum 71, view 5
Circadia Serum 71, view 6
Approx. 6 to 8 Week Supply

Circadia Serum 71

A multi-acid, immune-boosting serum that brightens, firms and refines with tranexamic, mandelic & azelaic acids plus Neodermyl® and advanced beta glucan.

This product isn't available to buy online. For prices, advice or to place an order, please get in touch.
WhatsApp Us Call Us

AVAILABLE TO MESSAGE 24/7 we will respond during normal working hours

Lines open Mon - Fri 9am - 5pm

Helps with

PigmentationFine lines and wrinkles

Tap a tag to see more products for your skin, or take the skin quiz for a full routine.

Circadia Serum 71 is a powerhouse, immune-boosting serum designed to transform dull, stressed and uneven skin. This nutrient-rich formula combines a next-generation blend of tranexamic, mandelic and azelaic acids with advanced skin-repairing actives to deliver visible brightening, wrinkle reduction and overall improved skin health.

At the heart of the formula is Neodermyl®: an award-winning copper peptide known as the “needle-free filler”, proven to help stimulate collagen and elastin for firmer, more lifted skin. A second-generation Beta Glucan strengthens the skin’s immune response while soothing inflammation and boosting recovery.

Mandelic Acid (5%) and Tranexamic Acid (2%) work synergistically to inhibit tyrosinase activity, reduce pigmentation and even skin tone, while Azelaic Acid (0.3%) calms redness, minimises blemishes and supports a clearer complexion.

This multi-action serum brightens, refines, strengthens and hydrates, making it an exceptional all-round treatment for ageing, uneven, reactive or acne-prone skin.

Benefits

  • Visibly improves overall skin health and resilience.
  • Brightens and reduces hyperpigmentation by inhibiting tyrosinase.
  • Minimises fine lines and wrinkles with collagen-boosting technology.
  • Soothes irritated or sensitised skin.
  • Provides antioxidant protection.
  • Helps reduce bacteria and impurities linked to blemishes.

Key Ingredients

  • Neodermyl®: A next-generation copper peptide often referred to as a “needle-free filler”; boosts collagen and elastin for firmer, more lifted skin.
  • CM-Glucan Forte: Advanced beta glucan for immune support, skin recovery and improved barrier strength.
  • Mandelic Acid (5%): A gentle AHA that brightens, smooths and helps inhibit pigment production.
  • Azelaic Acid (0.3%): Reduces redness, discolouration, congestion and blemish-related irritation.
  • Tranexamic Acid (2%): A powerful brightener that improves hyperpigmentation while strengthening skin barrier function.

A results-driven, corrective serum for anyone seeking brighter, stronger, healthier-looking skin.

Nightly after cleansing apply a drop (0.1 g) to affected areas on face and neck, avoiding eye area.

15ml

Aqua/Water, Propanediol, Mandelic Acid, Butylene Glycol, Tranexamic Acid, Sodium PCA, Glycerin, Methyl Glucoside Phosphate Proline Lysine Copper Complex, Azelaic Acid, Magnesium Carboxymethyl Beta-Glucan, Hydroxyethyl cellulose, Phenoxyethanol

Circadia

Circadia is a science-led professional skincare brand founded by Dr. Peter T. Pugliese, a pioneer in skin chronobiology. The line is built around the principle that the skin’s needs differ during day and night, and that treatment success depends on working with the body’s natural rhythms.

The range combines advanced peptide technology, innovative delivery systems, and botanicals to address ageing, pigmentation, acne and sensitive skin. In the clinic, Circadia protocols focus on repairing and protecting by day and stimulating repair at night, while its homecare extends professional results.

With an emphasis on education and ongoing research, Circadia partners with skin professionals worldwide to deliver evidence-based skincare that synchronises with the body for visible, long-lasting results.

Glycerin, Mandelic Acid, Peptides, AHAs / BHAs / PHAs, Hyaluronic Acid

Find your Circadia routine

Take our Circadia skin quiz, then our team will help with pricing and ordering.

Take the quiz

Need personalised advice?

Speak to our skincare team for advice tailored to your skin.

Get in touch
Your Bag
Shipping calculated at checkout
Go to bag
  • Visa
  • Mastercard
  • American Express
  • Apple Pay
  • Google Pay
  • PayPal
  • Klarna
  • Clearpay
Ingredient
Glycerin
What It Is

Glycerin works as a humectant, it attracts moisture from the air into the stratum corneum (top layer of skin), and due to its low molecular weight, will continue to draw moisture to the deeper layers of the dermis.

Glycerin also treats several skin disorders, ranging from dry skin to wound healing. The ingredient has the potential of improving your overall internal health as well.

Due to its versatility and ability to moisturise, it’s used in everything from lotions to soaps to toners.

What It Does

How to use in your skincare routine?

Products with glycerin can be used topically multiple times a day. You can safely and effectively use this ingredient in nearly every single step of your skin care routine. Several skin care brands use glycerin when formulating everything from cleansers and toners, to serums and moisturisers.

Benefits
  • Glycerin tightens and firms - Use this ingredient for a few weeks or even a few days and we think you'll find that it plumps and softens your look significantly, especially if you have more mature skin.
  • It improves your complexion - Glycerin is non-comedogenic, meaning it won’t clog pores.
  • It brightens - Between glycerin’s rejuvenating properties and its ability to moisturise, glycerin plays a key role in keeping skin looking bright and luminous.
  • The ingredient is also a good choice for sensitive skin. Because it’s a natural component of skin, it calms redness and inflammation. It’s one of the gentler ingredients you can find in skin care products and can even help alleviate sensitivity over time.
Mandelic Acid
What It Is

Mandelic acid is derived from bitter almonds. It’s an AHA that’s been mostly studied for use with acne. AHAs are natural and synthetic ingredients that provide skin care benefits ranging from exfoliation to increasing hydration and firmness.

What It Does

You need to consider doing a patch test before using mandelic acid for the first time to see if they can tolerate it. People should start at lower concentrations and apply it no more than once a week.

You should also avoid using it with other chemical peels and exfoliants, such as retinol, other AHAs, and beta hydroxy acids (BHAs). Overusing chemical peels and exfoliants may lead to over-exfoliation, which can cause skin sensitivity and breakouts.

Acids may also dry the skin. After using mandelic acid to help soothe and moisturise the skin, a person can apply hydrating products, such as moisturisers.

Benefits

One main benefit of mandelic acid is that it may be more gentle on the skin compared to other AHAs. This makes it an ideal choice for those with sensitive skin. This gentleness seems to be due to mandelic acid being one of the largest AHAs, and as a result, it penetrates the skin at a slower rate. This makes it less irritating on the skin.

Mandelic acid also improves skin appearance because it promotes collagen production, which is the main protein found in skin and connective tissue.

Results from using this acid vary from person to person, but some people notice a difference in their complexion and appearance after a couple of weeks.

 

Peptides
AHAs / BHAs / PHAs
What It Is

The world of acids can be divided into a few categories, three to be precise: Alpha Hydroxy Acids (AHAs), Beta Hydroxy Acids (BHAs) and the underdog, Polyhydroxy Acids (PHAs). If you're using a skincare acid, it'll fall into one of these three categories.

AHAs

These may ring some bells as you're bound to find an AHA already hiding in your skincare routine. AHAs are chemical exfoliators that can be extremely helpful for oily or blemish-prone skin if used on a regular basis.
The top dogs in this category are Glycolic Acid and Lactic Acid. You can find them mixed in with serums, moisturisers, cleansers and toners, depending on how high of a dosage you want to use (the smaller the percentage, the less potent the formula).

BHAs

Whilst they are also chemical exfoliators, AHAs and BHAs treat different skin problems.
AHAs are ideal for those concerned with ageing skin, whereas BHAs are best for those who are one the oilier side of the skincare spectrum and struggle with acne, blackheads and milia (the little white bumps you sometimes see under the skin).
Whilst AHAs are only water soluble, BHAs are oil soluble, which is why they are ideal for those struggling with an oil-slick T-zone. They can get below the oil that’s clogging up your skin and also have antibacterial and anti-inflammatory properties. So they help spots disappear quicker and calm any redness.
The most popular BHA is Salicylic Acid. It can be found in a range of different formulas targeted at spot treatments.

PHAs

The underdog of the acid trilogy, PHAs don't get the praise they deserve.

"PHAs (AKA Polyhydroxy Acids) are very similar to traditional alpha hydroxy acids, because both work by breaking down the 'glue' that binds dull, dead cells to the surface of the skin." Daniel Isaacs, Scientific Director at Medik8

They're especially beneficial for those who find other acids too strong. 'Even very sensitive skin types can harness the resurfacing powers of PHAs,' says Daniel. 'In clinical studies, they have been proven to be compatible with dry, itchy skin conditions such as eczema and atopic rosacea.'
The most common PHA acids are Gluconolactone, Galactose and Lactobionic - bit of a mouthful to say but well worth looking out for the next time you’re in the market for a new chemical exfoliant.

Hyaluronic Acid
What It Is

Hyaluronic-acid a substance that retains moisture and is capable of binding over one thousand times its weight in water. This substance is naturally found in many areas of the human body, including the skin, eyes, and synovial fluid of the joints.

As we age, the production of key substances in the skin, including hyaluronic acid (along with collagen and elastin) decreases. As a result, our skin loses volume, hydration, and plumpness.

The substance works as a magnet for moisture, helping your cells retain as much of it as possible so that your skin feels and appears hydrated, plump and healthy.

What It Does

Moisturisers and serums are two of the most common form of hyaluronic acid.

  • Moisturisers. Use a moisturiser infused with hyaluronic acid at the time when you’d usually moisturise. Ideally, this would be 2 times a day and always after cleansing, exfoliating, or applying serums.
  • Serums. A hyaluronic acid serum involves a slightly different routine. After cleansing, use a toner on your skin and press a couple of drops of your serum into your face with the palms of your hands. Don’t forget to apply a moisturiser immediately afterward to seal in all that hydration.

This acid also plays well with most other skin actives, making it easy to pair with peels, retinols, vitamins, and other acids.

Benefits

When used in skincare products, including creams and serums, hyaluronic acid gives your complexion a boost by quickly increasing the skin's moisture level. It’s especially useful for reducing the appearance of wrinkles and age lines.